Lrp2 / Megalin Recombinant Rabbit Monoclonal Antibody [PSH02-91]

Catalog number HA721910

Price for HA721910

Size / count 100 µL

About this product

LRP2 was identified as the antigen of rat experimental membranous nephropathy (Heyman nephritis) and originally named gp330 and subsequently megalin and later LRP2. LRP2/megalin is a multiligand binding receptor found in the plasma membrane of many absorptive epithelial cells. LRP2 is an approximately 600kDa (4665 amino acids) transmembrane glycoprotein with structural similarities to the low density lipoprotein receptor (LDLR). LRP2 has a NPXY motif that is the binding site for Dab2 to initiate clathrin-mediated endocytosis. LRP2 forms a homodimer that changes conformation in response to pH. At pH 7.5 (extracellular pH), LRP2 is considered active, with the leucine loops in an open conformation to allow ligands to bind.[11] At acidic endosomal pHs, the leucine loops collapse to prevent ligands binding.

Specifications

Catalog number: HA721910
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Calcium sensor protein antibody DBS antibody Glycoprotein 330 antibody gp330 antibody Heymann nephritis antigen homolog antibody Low-density lipoprotein receptor-related protein 2 antibody LRP-2 antibody Lrp2 antibody LRP2_HUMAN antibody Megalin antibody
Abbreviation: Low-density lipoprotein receptor-related protein 2 LRP2 LRP-2 Glycoprotein 330 (gp330) Megalin
Swiss Prot: P98164 Human
Cellular Locus: Apical cell membrane, Endosome lumen, Membrane, coated pit, Cell projection, dendrite, axon.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within human Lrp2 aa 2,500-3,200 / 4,655.
Isotype: IgG
Clone: PSH02-91
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: IHC-P, IF-Tissue, WB
Positive Control: Human kidney tissue lysates, human kidney tissue, human liver tissue.
Concentration: 1 mg/mL
Dilution: IHC-P: 1:1,000 ;IF-Tissue: 1:50 ;WB: 1:2,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 522 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Lrp2 / Megalin Recombinant Rabbit Monoclonal Antibody [PSH02-91]?

The catalog number for Lrp2 / Megalin Recombinant Rabbit Monoclonal Antibody [PSH02-91] is HA721910.

What sizes are available for Lrp2 / Megalin Recombinant Rabbit Monoclonal Antibody [PSH02-91]?

Lrp2 / Megalin Recombinant Rabbit Monoclonal Antibody [PSH02-91] is available in the following size(s): 100 µL.

Is Lrp2 / Megalin Recombinant Rabbit Monoclonal Antibody [PSH02-91] in stock?

Lrp2 / Megalin Recombinant Rabbit Monoclonal Antibody [PSH02-91] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Lrp2 / Megalin Recombinant Rabbit Monoclonal Antibody [PSH02-91] used for?

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.

How long will it take to receive this product if it’s custom made?

Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.

What is the recommended dilution for this antibody?

A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.