Cdk4 Recombinant Mouse Monoclonal Antibody [5-C3-G3-R]

Catalog number HA601227

Price for HA601227

Size / count 100 µL

About this product

Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression . Another family of proteins, Cdk inhibitors, also plays a role in regulating the cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Several Cdk proteins have been identified, including Cdk2-Cdk8, PCTAIRE-1-PCTAIRE-3, PITALRE and PITSLRE. Cdk4, in complex with D-type cyclins, is thought to regulate cell growth during the G1 phase of the cell cycle. This association with a D-type cyclin upregulates Cdk4 activity, whereas binding to the Cdk inhibitor p16 downregulates Cdk4 activity. Activation of the Cdk4-cyclin complexes requires phosphorylation on a single threonyl residue of Cdk4, catalyzed by a Cdk-activating protein (CAK).

Specifications

Catalog number: HA601227
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Cdk 4 antibody cdk4 antibody CDK4 protein antibody CDK4_HUMAN antibody Cell division kinase 4 antibody Cell division protein kinase 4 antibody CMM 3 antibody CMM3 antibody Crk3 antibody Cyclin dependent kinase 4 antibody Cyclin-dependent kinase 4 antibody Melanoma cutaneous malignant 3 antibody MGC14458 antibody p34 cdk4 antibody PSK J3 antibody PSK-J3 antibody
Abbreviation: CDK4
Swiss Prot: P11802 Human, P30285 Mouse
Cellular Locus: Cytoplasm, Nucleus, Nucleus membrane.
Host: Mouse
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within human Cdk4 aa 80-303/303.
Isotype: IgG1
Clone: 5-C3-G3-R
Conjugation: Non-conjugated
Type: Recombinant Mouse monoclonal Antibody
Applications: WB
Positive Control: A549 cell lysate, 293T cell lysate, HeLa cell lysate, MCF7 cell lysate, K-562 cell lysate.
Concentration: 2 mg/mL
Dilution: WB: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 34 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Cdk4 Recombinant Mouse Monoclonal Antibody [5-C3-G3-R]?

The catalog number for Cdk4 Recombinant Mouse Monoclonal Antibody [5-C3-G3-R] is HA601227.

What sizes are available for Cdk4 Recombinant Mouse Monoclonal Antibody [5-C3-G3-R]?

Cdk4 Recombinant Mouse Monoclonal Antibody [5-C3-G3-R] is available in the following size(s): 100 µL.

Is Cdk4 Recombinant Mouse Monoclonal Antibody [5-C3-G3-R] in stock?

Cdk4 Recombinant Mouse Monoclonal Antibody [5-C3-G3-R] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Cdk4 Recombinant Mouse Monoclonal Antibody [5-C3-G3-R] used for?

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.