Human TNF alpha Recombinant Rabbit Monoclonal Antibody [PS00-40]

Catalog number HA721286

Price for HA721286

Size / count 100 µL

About this product

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.

Specifications

Catalog number: HA721286
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: APC1 antibody APC1 protein antibody Cachectin antibody DIF antibody Differentiation inducing factor antibody Macrophage cytotoxic factor antibody Tnf antibody TNF superfamily member 2 antibody TNF superfamily, member 2 antibody TNF, macrophage derived antibody TNF, monocyte derived antibody TNF-a antibody TNF-alpha antibody TNFA antibody TNFA_HUMAN antibody TNFSF2 antibody Tumor necrosis factor (TNF superfamily member 2) antibody Tumor necrosis factor alpha antibody Tumor necrosis factor antibody Tumor necrosis factor ligand superfamily member 2 antibody Tumor Necrosis Factor, Membrane Form antibody Tumor necrosis factor, soluble form antibody
Abbreviation: Tumor necrosis factor Cachectin TNF-alpha Tumor necrosis factor ligand superfamily member 2 (TNF-a) Tumor necrosis factor, membrane form Alternative names: N-terminal fragment (NTF) Intracellular domain 1 (ICD1) Intracellular domain 2 (ICD2) C-domain 1 C-domain 2 Tumor necrosis factor, soluble form TNF TNFA, TNFSF2
Swiss Prot: P01375 Human
Cellular Locus: Cell membrane, Secreted.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within full length protein.
Isotype: IgG
Clone: PS00-40
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: IHC-P
Positive Control: Human pancreas tissue.
Concentration: 1mg/mL
Dilution: IHC-P: 1:200-1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 26 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Human TNF alpha Recombinant Rabbit Monoclonal Antibody [PS00-40]?

The catalog number for Human TNF alpha Recombinant Rabbit Monoclonal Antibody [PS00-40] is HA721286.

What sizes are available for Human TNF alpha Recombinant Rabbit Monoclonal Antibody [PS00-40]?

Human TNF alpha Recombinant Rabbit Monoclonal Antibody [PS00-40] is available in the following size(s): 100 µL.

Is Human TNF alpha Recombinant Rabbit Monoclonal Antibody [PS00-40] in stock?

Human TNF alpha Recombinant Rabbit Monoclonal Antibody [PS00-40] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Human TNF alpha Recombinant Rabbit Monoclonal Antibody [PS00-40] used for?

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.