Fibronectin (TV-1), CF740 conjugate, 0.1mg/mL

About this product

Fibronectin is a soluble dimeric glycoprotein of 440 kDa, which is present in cells, extracellular matrix, and blood. This MAb reacts with the cellular as well as plasma form of fibronectin. Reportedly, after iv administration, this MAb localizes to tumor vessels where it binds to the underlying basement. The epitope recognized by this antibody is not accessible to the circulating MAb in normal tissues, indicating that it can be used to specifically target tumor vessels in vivo. TV-1 is reportedly useful for delivering vasoactive agents to tumors to induce increased vascular permeability or blood flow prior to treatment with chemotherapeutic drugs or MAbs.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNC740029-500

Size / count

1x 500 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

Cold insoluble globulin (CIG) ; FINC; FN1; FNZ; GFND; GFND2; LETS; Migration stimulating factor (MSF) ; Ugl-Y3

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

FN1

Gene ID

2335

NCBI Gene ID

203717

UniProt

P02751

Swiss Prot

P02751

Host

Mouse

Species Reactivity

Human, Mouse, Pig, Rat

Reactivity

Fibronectin

Immunogen

T-cell lymphoma biopsy

Target Antigen

Fibronectin

Clonality

Monoclonal

Clone

TV-1

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow, surface (published) |IHC, frozen (published) |IHC, FFPE (verified) |WB (published)

Field of Research

Cell adhesion, Extracellular matrix

Positive Control

SW156 cells or Kidney

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% rBSA, 0.05% azide

Molecular Weight

220 kDa (monomer) ; 440 kDa (dimer)

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. Cancer Res (1995) 55: 2673-2680. (IHC, frozen; WB; in vivo tumor targeting) BMC Cancer (2006) 6: 8. (Flow, surface)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Notes

Protect from light

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse), Bos taurus (bovine)

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

CF740