CD59 (heavy chain of Protectin) (MACIF/629), CF740 conjugate, 0.1mg/mL — image 1 of 2

Product details

CD59 (heavy chain of Protectin) (MACIF/629), CF740 conjugate, 0.1mg/mL

Catalog number BNC740629-100

Price for BNC740629-100

Size / count 1x 100 µL

About this product

Reacts with human CD59, a 20 kDa glycosyl phosphatidyl-inositol (GPI) -anchored cell surface protein. CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH) . This MAb is useful for study on GPI-anchored proteins, PNH and CD59 functions. CD59 is widely distributed on cells in all tissues. The expression of CD59 on erythrocytes is important for their survival.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC740629-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: 20kDa homologous restriction factor (HRF20) ; Complement regulatory protein; Human leukocyte antigen MIC11; MAC-inhibitory protein (MACIP) ; Membrane attack complex inhibition factor (MACIF) ; Membrane inhibitor of reactive lysis; MIRL; MSK21; Protectin; T cell activating protein
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: CD59
Gene ID: 966
NCBI Gene ID: 278573; 709466; 710641
UniProt: P13987
Swiss Prot: P13987
Host: Mouse
Species Reactivity: Human
Reactivity: CD59
Immunogen: Recombinant full-length human CD59 protein
Target Antigen: CD59
Clonality: Monoclonal
Clone: MACIF/629
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Hematology, Immunology
Positive Control: Daudi, CEM, K562, HPB.ALL, Jurkat, Raji, and human lymphocytes. Tonsil, Cervix or Bladder.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% rBSA, 0.05% azide
Molecular Weight: 20 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), Bos taurus (bovine)
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF740

Frequently Asked Questions

What is the catalog number for CD59 (heavy chain of Protectin) (MACIF/629), CF740 conjugate, 0.1mg/mL?

The catalog number for CD59 (heavy chain of Protectin) (MACIF/629), CF740 conjugate, 0.1mg/mL is BNC740629-100.

What sizes are available for CD59 (heavy chain of Protectin) (MACIF/629), CF740 conjugate, 0.1mg/mL?

CD59 (heavy chain of Protectin) (MACIF/629), CF740 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is CD59 (heavy chain of Protectin) (MACIF/629), CF740 conjugate, 0.1mg/mL in stock?

CD59 (heavy chain of Protectin) (MACIF/629), CF740 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures CD59 (heavy chain of Protectin) (MACIF/629), CF740 conjugate, 0.1mg/mL?

CD59 (heavy chain of Protectin) (MACIF/629), CF740 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for CD59 (heavy chain of Protectin) (MACIF/629), CF740 conjugate, 0.1mg/mL?

Estimated delivery time for CD59 (heavy chain of Protectin) (MACIF/629), CF740 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for CD59 (heavy chain of Protectin) (MACIF/629), CF740 conjugate, 0.1mg/mL?

The safety data sheet for CD59 (heavy chain of Protectin) (MACIF/629), CF740 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02a0061270361e103c80/msds/bnc740629-100.pdf.

What is CD59 (heavy chain of Protectin) (MACIF/629), CF740 conjugate, 0.1mg/mL used for?

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.