P53 (DO-7), CF740 conjugate, 0.1mg/mL

Catalog number BNC740513-500

Price for BNC740513-500

Size / count 1x 500 µL

About this product

Recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 37-45) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 MAb to p53 in an ELISA test. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC740513-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Antigen NY-CO-13, BCC7, Cellular Tumor Antigen p53, LFS1, TP53, Transformation Related Protein 53 (TRP53), Tumor Protein p53, Tumor Suppressor p53
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: TP53
Gene ID: 7157
NCBI Gene ID: 654481
UniProt: P04637
Swiss Prot: P04637
Host: Mouse
Species Reactivity: Cow, Human, Monkey
Reactivity: P53 Tumor Suppressor Protein
Immunogen: Recombinant human wild type p53 protein expressed in E. coli.
Target Antigen: p53 Tumor Suppressor Protein
Clonality: Monoclonal
Clone: DO-7
Type: Primary
Source: Animal
Origin: Animal
Field of Research: Apoptosis, Tumor suppressors
Positive Control: MDA-MB-231 Cells. Breast or Colon carcinoma
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% rBSA, 0.05% azide
Molecular Weight: 53 kDa
References & Citations: Vojtesek B et al. 1992. J. Immunol. Methods. 151(1-2): 237-44. | Stephen CW et al. 1995. J Mol. Biol. 248(1): 58-78. |
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Species: Mus musculus (mouse), Bos taurus (bovine)
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF740

Frequently Asked Questions

What is the catalog number for P53 (DO-7), CF740 conjugate, 0.1mg/mL?

The catalog number for P53 (DO-7), CF740 conjugate, 0.1mg/mL is BNC740513-500.

What sizes are available for P53 (DO-7), CF740 conjugate, 0.1mg/mL?

P53 (DO-7), CF740 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is P53 (DO-7), CF740 conjugate, 0.1mg/mL in stock?

P53 (DO-7), CF740 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures P53 (DO-7), CF740 conjugate, 0.1mg/mL?

P53 (DO-7), CF740 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for P53 (DO-7), CF740 conjugate, 0.1mg/mL?

Estimated delivery time for P53 (DO-7), CF740 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for P53 (DO-7), CF740 conjugate, 0.1mg/mL?

The safety data sheet for P53 (DO-7), CF740 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02b1061270361e1099b2/msds/bnc740513-500.pdf.

What is P53 (DO-7), CF740 conjugate, 0.1mg/mL used for?

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.

Is this antibody conjugated?

Conjugation status, such as unconjugated, HRP, FITC, or biotin, is specified in the product name and confirmed on the datasheet.

What is the sensitivity of this ELISA kit?

Assay sensitivity, including the minimum detectable dose, is listed on the datasheet. Kits that are assembled on order typically ship within 2-4 weeks.