DNMT1 Recombinant Mouse Monoclonal Antibody [A3A8-R]

Catalog number HA601281

Price for HA601281

Size / count 100 µL

About this product

Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. Promotes tumor growth.

Specifications

Catalog number: HA601281
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: ADCADN antibody AIM antibody CXXC finger protein 9 antibody CXXC-type zinc finger protein 9 antibody CXXC9 antibody DNA (cytosine 5 ) methyltransferase 1 antibody DNA (cytosine-5)-methyltransferase 1 antibody DNA methyltransferase 1 antibody DNA methyltransferase HsaI antibody DNA methyltransferase M.HsaI. antibody DNA MTase antibody DNA MTase HsaI antibody DNMT 1 antibody DNMT antibody Dnmt1 antibody DNMT1_HUMAN antibody Dnmt1o antibody FLJ16293 antibody HSN1E antibody M.HsaI antibody MCMT antibody Met1 antibody MGC104992 antibody mMmul antibody MommeD2 antibody
Abbreviation: DNMT1
Swiss Prot: P26358 Human
Cellular Locus: Nucleus.
Host: Mouse
Species Reactivity: Human
Immunogen: Synthetic peptide within Human Dnmt1 aa 500-600 / 1616.
Isotype: IgG1
Clone: A3A8-R
Conjugation: Non-conjugated
Type: Recombinant Mouse monoclonal Antibody
Applications: WB, IF-Cell
Positive Control: HeLa cell lysate, 293T cell lysate, HepG2 cell lysate, Jurkat cell lysate, HeLa.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;IF-Cell: 1:100
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 183 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for DNMT1 Recombinant Mouse Monoclonal Antibody [A3A8-R]?

The catalog number for DNMT1 Recombinant Mouse Monoclonal Antibody [A3A8-R] is HA601281.

What sizes are available for DNMT1 Recombinant Mouse Monoclonal Antibody [A3A8-R]?

DNMT1 Recombinant Mouse Monoclonal Antibody [A3A8-R] is available in the following size(s): 100 µL.

Is DNMT1 Recombinant Mouse Monoclonal Antibody [A3A8-R] in stock?

DNMT1 Recombinant Mouse Monoclonal Antibody [A3A8-R] is currently made to order / not held in immediate stock. Contact us for lead time.

What is DNMT1 Recombinant Mouse Monoclonal Antibody [A3A8-R] used for?

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.