DcR1 Recombinant Rabbit Monoclonal Antibody [JE58-51]

About this product

Decoy receptor 1 (DCR1), also known as TRAIL receptor 3 (TRAILR3) and tumor necrosis factor receptor superfamily member 10C (TNFRSF10C), is a human cell surface receptor of the TNF-receptor superfamily. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.

Specifications

Catalog number

HA721475

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Antagonist decoy receptor for TRAIL/Apo 2L antibody Antagonist decoy receptor for TRAIL/Apo-2L antibody CD263 antibody Cytotoxic TRAIL receptor 3 antibody DcR1 antibody DCR1 TNFR antibody Decoy receptor 1 antibody Decoy TRAIL receptor without death domain antibody LIT antibody Lymphocyte inhibitor of TRAIL antibody MGC149501 antibody MGC149502 antibody TNF related apoptosis inducing ligand receptor 3 antibody TNF-re ated apoptosis inducing ligand receptor 3 antibody TNF-related apoptosis-inducing ligand receptor 3 antibody TNFRSF10C antibody TR10C_HUMAN antibody TRAIL R3 antibody TRAIL receptor 3 antibody Trail receptor without an intracellular domain antibody TRAIL-R3 antibody TRAILR3 antibody TRID antibody Tumor necrosis factor receptor superfamily member 10C antibody Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain antibody

Abbreviation

TNFRSF10C, DCR1, LIT, TRAILR3, TRID

Swiss Prot

O14798 Human

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human DcR1 aa 200-300.

Isotype

IgG

Clone

JE58-51

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, FC

Positive Control

JAR cell lysate, Jurkat cell lysate, A549 cell lysate, HeLa cell lysate, Raji cell lysate, Jurkat.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:100 ;FC: 1:500-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 27 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes