ABL1 Recombinant Rabbit Monoclonal Antibody [PSH04-08]

About this product

Tyrosine-protein kinase ABL1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL) located on chromosome 9. c-Abl is sometimes used to refer to the version of the gene found within the mammalian genome, while v-Abl refers to the viral gene, which was initially isolated from the Abelson murine leukemia virus. The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response such as DNA repair. Activity of ABL1 protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t (9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes, leading to a fusion gene present in many cases of chronic myelogenous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or a 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2–11.

Specifications

Catalog number

HA722089

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Abelson murine leukemia viral oncogene homolog 1 antibody Abelson tyrosine protein kinase 1 antibody Abl 1 antibody ABL antibody ABL proto oncogene 1 non receptor tyrosine kinase antibody ABL1 antibody ABL1_HUMAN antibody bcr/abl antibody bcr/c abl oncogene protein antibody c ABL antibody c abl oncogene 1 non receptor tyrosine kinase antibody c abl oncogene 1 receptor tyrosine kinase antibody c ABL1 antibody JTK7 antibody p150 antibody Proto oncogene tyrosine protein kinase ABL1 antibody Proto-oncogene c-Abl antibody Tyrosine-protein kinase ABL1 antibody v abl Abelson murine leukemia viral oncogene homolog 1 antibody v abl antibody

Abbreviation

ABL1, ABL, JTK7

Swiss Prot

P00519 Human, P00520 Mouse

Cellular Locus

Cytoplasm, cytoskeleton, Nucleus, Mitochondrion; Nucleus membrane.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant protein within human ABL1 aa 601-1,000 / 1,130.

Isotype

IgG

Clone

PSH04-08

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

K-562 cell lysate, HeLa cell lysate, Daudi cell lysate, THP-1 cell lysate, K-562, human breast cancer tissue, human lung cancer tissue, mouse kidney tissue, HeLa.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:100 ;IHC-P: 1:200 ;FC: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 123 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes