- Home
- Shop
- New Categories
- New Blog
- Contact Us
- Cart
- Login
- Register
![GPD2 Recombinant Rabbit Monoclonal Antibody [PSH0-31] — image 1 of 1](https://cdn.genprice.uk/products/992/68dd1c8a061270361ea812c6/imageurl/ha721311.webp)
Select the image to view it full size.
Product details
Catalog number HA721311
Price for HA721311
Size / count 100 µL
Mitochondrial glycerol-3-phosphate dehydrogenase (GPD2), catalyzes the irreversible oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate and concomitantly transfers two electrons from FAD to the electron transport chain. GPD2 consists of 4 identical subunits. Studies indicate that GPDH is mostly unaffected by pH changes: neither GPD1 or GPD2 is favored under certain pH conditions. At high salt concentrations (E.g. NaCl), GPD1 activity is enhanced over GPD2, since an increase in the salinity of the medium leads to an accumulation of glycerol in response. Changes in temperature do not appear to favor neither GPD1 nor GPD2. The fundamental role of GPDH in maintaining the NAD+/NADH potential, as well as its role in lipid metabolism, makes GPDH a factor in lipid imbalance diseases, such as obesity. Enhanced GPDH activity, particularly GPD2, leads to an increase in glycerol production. Since glycerol is a main subunit in lipid metabolism, its abundance can easily lead to an increase in triglyceride accumulation at a cellular level. As a result, there is a tendency to form adipose tissue leading to an accumulation of fat that favors obesity. GPDH has also been found to play a role in Brugada syndrome. Mutations in the gene encoding GPD1 have been proven to cause defects in the electron transport chain. This conflict with NAD+/NADH levels in the cell is believed to contribute to defects in cardiac sodium ion channel regulation and can lead to a lethal arrythmia during infancy.
The catalog number for GPD2 Recombinant Rabbit Monoclonal Antibody [PSH0-31] is HA721311.
GPD2 Recombinant Rabbit Monoclonal Antibody [PSH0-31] is available in the following size(s): 100 µL.
GPD2 Recombinant Rabbit Monoclonal Antibody [PSH0-31] is currently made to order / not held in immediate stock. Contact us for lead time.
Mitochondrial glycerol-3-phosphate dehydrogenase (GPD2), catalyzes the irreversible oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate and concomitantly transfers two electrons from FAD to the electron transport chain. GPD2 consists of 4 identical subunits. Studies indicate that GPDH is
As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.
Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.
Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.
