Product details
Catalog number HA721557
Price for HA721557
Size / count 100 µL
DNA replication licensing factor MCM4 is a protein that in humans is encoded by the MCM4 gene. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
The catalog number for MCM4 Recombinant Rabbit Monoclonal Antibody [JE38-76] is HA721557.
MCM4 Recombinant Rabbit Monoclonal Antibody [JE38-76] is available in the following size(s): 100 µL.
MCM4 Recombinant Rabbit Monoclonal Antibody [JE38-76] is currently made to order / not held in immediate stock. Contact us for lead time.
DNA replication licensing factor MCM4 is a protein that in humans is encoded by the MCM4 gene. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein comp
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