Anti-DNAJC2 Antibody

About this product

Boster Bio Anti-DNAJC2 Antibody catalog # A06788. Tested in WB applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A06788

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

DnaJ homolog subfamily C member 2; M-phase phosphoprotein 11; Zuotin-related factor 1; DnaJ homolog subfamily C member 2, N-terminally processed; DNAJC2; MPHOSPH11, MPP11, ZRF1;

Gene Name

DNAJC2

UniProt

Q99543

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein of human DNAJC2 (NP_055192.1) .

Clonality

Polyclonal

Tissue Specificity

Widely expressed.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Dilution

WB: 1:500-1:2000

Form

Liquid

Function

Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.

Molecular Weight

71996 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

DnaJ homolog subfamily C member 2

Subcellular Location

Nucleus

Protein Name

DnaJ homolog subfamily C member 2