AF/LE Purified Anti-Human CD19 Antibody[4G7]

Specifications

Catalog number

E-AB-F11270-01

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD19 protein is a 95 kDa transmembrane glycoprotein that plays a central role in B cell activation and humoral immune responses . CD19 is expressed throughout B cell development from pre-B cells through mature B cells, and it is commonly used as a B cell lineage marker . It is required for the responsiveness of mature B cell to antigen stimulation, germinal center development, and antibody affinity maturation . The CD19 protein associates with the B cell antigen receptor (BCR), CD81, CD38, CD21, CD22, and IFITM1/CD225/Leu13. These associations enable CD19 to amplify B cell signaling and reduce the threshold for antigen stimulation through the BCR.

Abbreviation

CD19

Gene ID

930

UniProt

P15391

Host

Mouse

Reactivity

Human

Immunogen

Recombinant Human CD19 protein

Target

CVID; B-lymphocyteantigenCD; B-lymphocyte antigen CD; T-cellsurfaceantigenLeu; Differentiation antigen CD; T-cell surface antigen Leu; B-lymphocytesurfaceantigenB; B-lymphocyte surface antigen B; B4; CVID3; CD19; B-lymphocyteantigenCD19; B-lymphocytesurfaceantigenB4; T-cellsurfaceantigenLeu-12; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12; B4; CVID3; CD19; CD19 molecule

Clonality

Monoclonal

Clone

4G7

Conjugation

None (AF/LE)

Applications

FCM

Field of Research

Immunology; Stem Cells

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Isotype

Mouse IgG1, κ