Mouse IL-2 Recombinant Rabbit Monoclonal Antibody [PSH04-27] - BSA and Azide free (Capture)

Catalog number HA722110

Price for HA722110

Size / count 100 µL

About this product

Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.

Specifications

Catalog number: HA722110
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Aldesleukin antibody IL 2 antibody IL-2 antibody IL2 antibody IL2_HUMAN antibody Interleukin 2 antibody Interleukin-2 antibody interleukin2 antibody Involved in regulation of T cell clonal expansion antibody Lymphokine antibody OTTHUMP00000164090 antibody POIL2 antibody T Cell Growth Factor antibody T-cell growth factor antibody TCGF antibody
Abbreviation: Interleukin-2 IL-2 T-cell growth factor (TCGF) Il2 Il-2
Swiss Prot: P04351 Mouse
Cellular Locus: Secreted.
Host: Rabbit
Species Reactivity: Mouse
Immunogen: Recombinant protein within Mouse IL-2 aa 21-169 (P04351).
Isotype: IgG
Clone: PSH04-27
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: ELISA (Cap)
Positive Control: Recombinant Mouse IL-2 protein (HA210816).
Concentration: 1 mg/mL
Dilution: ELISA (Cap): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH04-28] to Mouse IL-2 (Detector) (HA722111) and recombinant standard Mouse IL-2 protein (HA210816). The reference range value is 30.9-2500 pg/ml.
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4).
Molecular Weight: Predicted band size: 19.4 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Mouse IL-2 Recombinant Rabbit Monoclonal Antibody [PSH04-27] - BSA and Azide free (Capture)?

The catalog number for Mouse IL-2 Recombinant Rabbit Monoclonal Antibody [PSH04-27] - BSA and Azide free (Capture) is HA722110.

What sizes are available for Mouse IL-2 Recombinant Rabbit Monoclonal Antibody [PSH04-27] - BSA and Azide free (Capture)?

Mouse IL-2 Recombinant Rabbit Monoclonal Antibody [PSH04-27] - BSA and Azide free (Capture) is available in the following size(s): 100 µL.

Is Mouse IL-2 Recombinant Rabbit Monoclonal Antibody [PSH04-27] - BSA and Azide free (Capture) in stock?

Mouse IL-2 Recombinant Rabbit Monoclonal Antibody [PSH04-27] - BSA and Azide free (Capture) is currently made to order / not held in immediate stock. Contact us for lead time.

What is Mouse IL-2 Recombinant Rabbit Monoclonal Antibody [PSH04-27] - BSA and Azide free (Capture) used for?

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.

Is this antibody conjugated?

Conjugation status, such as unconjugated, HRP, FITC, or biotin, is specified in the product name and confirmed on the datasheet.

What is the sensitivity of this ELISA kit?

Assay sensitivity, including the minimum detectable dose, is listed on the datasheet. Kits that are assembled on order typically ship within 2-4 weeks.