AF/LE Purified Anti-Mouse CD161/NK1.1 Antibody[PK136]

Specifications

Catalog number

E-AB-F09870-01

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.

Abbreviation

NK1.1

Gene ID

17059;80782

UniProt

P27814; P27812; Q99JB4

Host

Mouse

Reactivity

Mouse

Immunogen

Recombinant Mouse NK1.1 protein

Target

CD161 antigen-like family member C; CD161/NK1.1; CD161c; Killer cell lectin-like receptor subfamily B member 1C; Klrb1c; Ly-55c; NKR-P1 40; NKR-P1.9; NKR-P1C

Clonality

Monoclonal

Clone

PK136

Conjugation

None (AF/LE)

Applications

FCM

Field of Research

Immunology; Innate Immunity

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Recommended Usage

6

Isotype

Mouse IgG2a, κ