AF/LE Purified Anti-Mouse CD86 Antibody[GL-1]

Specifications

Catalog number

E-AB-F09940-01

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4) . CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

Abbreviation

CD86

Gene ID

12524

UniProt

P42082

Host

Rat

Reactivity

Mouse

Target

Activation B7-2 antigen; Cd86; ETC-1; Early T-cell costimulatory molecule 1; T-lymphocyte activation antigen CD86

Clonality

Monoclonal

Clone

GL-1

Conjugation

None (AF/LE)

Applications

FCM

Field of Research

Cell Biology; Costimulatory Molecules; Immunology; Neuroscience; Neuroscience Cell Markers

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Recommended Usage

6

Isotype

Rat IgG2a, κ