APC Anti-Mouse CD62L Antibody[MEL-14]

Specifications

Catalog number

E-AB-F1011UE-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD62L is a 74-95 kD glycoprotein also known as L-selectin, LECAM-1, Ly-22, LAM-1, and MEL-14. It is a member of the selectin family and is expressed on the majority of B and naïve T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte 'rolling' on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. CD62L has been reported to interact with CD34, GlyCAM-1, and MAdCAM-1.

Abbreviation

CD62L

Gene ID

20343

UniProt

P18337

Host

Rat

Reactivity

Mouse

Target

CD62L; CD62 antigen-like family member L; L-selectin; LAM-1; LECAM1; Lnhr; Ly-22; Ly22; Lymph node homing receptor; Sell

Clonality

Monoclonal

Clone

MEL-14

Conjugation

APC

Applications

FCM

Field of Research

Cell Adhesion; Cell Biology; Costimulatory Molecules; Immunology; Innate Immunity

Concentration

0.2 mg/mL

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation 01

https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.202207227

Recommended Usage

6

Isotype

Rat IgG2a, κ