Biotin Anti-Mouse CD272/BTLA Antibody[PK18.6]

Specifications

Catalog number

E-AB-F1024B-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naïve T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.

Abbreviation

CD272

Gene ID

208154

UniProt

Q7TSA3

Host

Rat

Reactivity

Mouse

Target

B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; Btla; CD272

Clonality

Monoclonal

Clone

PK18.6

Conjugation

Biotin

Applications

FCM

Field of Research

Immunology; Inhibitory Molecules

Concentration

0.5 mg/mL

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Do not freeze.

Recommended Usage

6

Isotype

Rat IgG1, κ