Purified Anti-Mouse CD122/IL-2RB Antibody[5H4]

Specifications

Catalog number

E-AB-F1029A-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.

Abbreviation

CD122

Gene ID

16185

UniProt

P16297

Host

Rat

Reactivity

Mouse

Immunogen

Recombinant Mouse CD122 protein

Target

IL-2R subunit beta; CD122; High affinity IL-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2RB; Il2rb; Interleukin-2 receptor subunit beta; p70-75

Clonality

Monoclonal

Clone

5H4

Conjugation

Unconjugated

Applications

FCM

Field of Research

Immunology

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

PBS, pH 7.2. Contains 0.05% proclin 300.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Recommended Usage

6

Isotype

Rat IgG2a, κ