PE/Cyanine5.5 Anti-Mouse CD122/IL-2RB Antibody[5H4]

Specifications

Catalog number

E-AB-F1029I-01

Size / count

50 Tests

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.

Abbreviation

CD122

Gene ID

16185

UniProt

P16297

Host

Rat

Reactivity

Mouse

Target

IL-2R subunit beta; CD122; High affinity IL-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2RB; Il2rb; Interleukin-2 receptor subunit beta; p70-75

Clonality

Monoclonal

Clone

5H4

Conjugation

PE/Cyanine 5.5

Applications

FCM

Field of Research

Immunology

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Rat IgG2a, κ