AF/LE Purified Anti-Mouse CD120b/TNFR2 Antibody[TR75-54.7]

Specifications

Catalog number

E-AB-F10350-01

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD120b is a 75 kD type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type II (TNFRII) or p75. It is expressed on a variety of cells at low levels; the expression is upregulated upon activation. This receptor binds both TNF-α and LT-α (also known as TNF-β) . In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-α or LT-α trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state.

Abbreviation

CD120b/TNFR2

Gene ID

21938

UniProt

P25119

Host

Armenian Hamster

Reactivity

Mouse

Target

CD120b; TNF-R2; TNF-RII; TNFR-II; Tnfrsf1b; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor superfamily member 1B; p75; p80 TNF-alpha receptor

Clonality

Monoclonal

Clone

TR75-54.7

Conjugation

None (AF/LE)

Applications

FCM; Block

Field of Research

Immunology; Innate Immunity

Concentration

≥ 1 mg/mL

Buffer

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Recommended Usage

6

Isotype

Armenian Hamster IgG