Purified Anti-Human CD47 Antibody[CC2C6D4]

Specifications

Catalog number

E-AB-F1060A-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, is a 42-52 kD member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. Two splice variants have been described in the cytoplasmic tail, the shorter form is expressed in bone-marrow-derived cells, endothelial cells, and fibroblasts while the longer form is expressed by neural tissues. CD47 expression is widely distributed in hematopoietic cells including thymocytes, T cells, B cells, monocytes, platelets, and erythrocytes as well as epithelial cells, endothelial cells, fibroblasts, and neural tissues. CD47 functions as an adhesion molecule and thrombospondin receptor and is non-covalently associated with β3 integrins CD51/CD61, CD41/CD61. Thrombospondin is a ligand for CD47; in the absence of CD47 mice show defects in host defense and β3 integrin-dependent ligand binding, migration, and cellular activation. CD47 is also part of the Rh complex on erythrocytes.

Abbreviation

CD47

Gene ID

961

UniProt

Q08722

Host

Mouse

Reactivity

Human

Target

Cd47; IAP; Integrin-associated protein; Leukocyte surface antigen CD47

Clonality

Monoclonal

Clone

CC2C6D4

Conjugation

Unconjugated

Applications

FCM

Field of Research

Immunology; Innate Immunity

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Recommended Usage

6

Isotype

Mouse IgG1, κ