Purified Anti-Mouse CD103 Antibody[M290]

Specifications

Catalog number

E-AB-F1090A-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL) . CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

Abbreviation

CD103

Gene ID

16407

UniProt

Q60677

Host

Rat

Reactivity

Mouse

Target

CD103; Integrin alpha M290; Integrin alpha-E; Itgae

Clonality

Monoclonal

Clone

M290

Conjugation

Unconjugated

Applications

FCM

Field of Research

Immunology

Concentration

≥ 1 mg/mL

Buffer

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Recommended Usage

6

Isotype

Rat IgG2a, κ