AF/LE Purified Anti-Human/Mouse CD44 Antibody[IM7]

Specifications

Catalog number

E-AB-F11000-01

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from low or mid levels to high levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. High CD44 expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.

Abbreviation

CD44

Gene ID

12505;960

UniProt

P15379; P16070

Host

Rat

Reactivity

Human; Mouse

Immunogen

Recombinant Human; Mouse CD44 protein

Target

MDU2; MDU3; MIC4; CD44; CD44 antigen; CDw44; Epican; LHR; PGP-1; PGP-I; Phagocytic glycoprotein 1; Phagocytic glycoprotein I

Clonality

Monoclonal

Clone

IM7

Conjugation

None (AF/LE)

Applications

FCM

Field of Research

Cell Adhesion; Cell Biology; Immunology; Stem Cells

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Recommended Usage

6

Isotype

Rat IgG2b, κ