AF/LE Purified Anti-Mouse CD115/CSF-1R Antibody[AFS98]

Specifications

Catalog number

E-AB-F11070-01

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.

Abbreviation

CD115

Gene ID

12978

UniProt

P09581

Host

Rat

Reactivity

Mouse

Immunogen

Recombinant Mouse CD115 protein

Target

CD115; CSF-1 receptor (EC:2.7.10.1) ; CSF-1-R; CSF-1R; Csf1r; Csfmr; Fms; M-CSF-R; Macrophage colony-stimulating factor 1 receptor; Proto-oncogene c-Fms

Clonality

Monoclonal

Clone

AFS98

Conjugation

None (AF/LE)

Applications

FCM

Field of Research

Immunology

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Recommended Usage

6

Isotype

Rat IgG2a, κ