AF/LE Purified Anti-Mouse CD119 Antibody[GR-20]

Specifications

Catalog number

E-AB-F11150-01

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CDw119 is a 90 kD immunoglobulin superfamily member, also known as IFN-γRα chain. It is a class II cytokine receptor family member that serves as a IFN-γ-binding chain associated with the IFN-γ β chain also known as AF-1. In addition to ligand binding, CDw119 participates in ligand trafficking. CDw119 is expressed on T and B cells, NK cells, fibroblasts, endothelial, and epithelial cells. Binding of IFN-γ induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. IFN-γ initiates and regulates a variety of immune responses.

Abbreviation

CD119

Gene ID

15979

UniProt

P15261

Host

Rat

Reactivity

Mouse

Target

CD119; IFN-gamma-R-alpha; IFN-gamma-R1; Ifngr1; Interferon gamma receptor 1

Clonality

Monoclonal

Clone

GR-20

Conjugation

None (AF/LE)

Applications

FCM

Field of Research

Immunology

Concentration

≥ 1 mg/mL

Buffer

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Recommended Usage

6

Isotype

Rat IgG2a, κ