Biotin Anti-Mouse CD49b/pan-NK cells Antibody[DX5]

Specifications

Catalog number

E-AB-F1116B-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

DX5 antigen has been recently characterized as CD49b. It is a 150 kD integrin α chain also known as α2 integrin, VLA-2 α chain, and integrin α2 chain. CD49b non-covalently associates with CD29 (β1 integrin) to form the CD49b/CD29 complex known as VLA-2, a receptor for collagen and laminin. CD49b is expressed on platelets, the majority of NK cells, NKT cells, and a small subset of CD8+ T cells (this population can be significantly increased following viral infection) . DX5 is used for the identification and isolation of NK cells, and is especially useful for identifying NK cells in mice lacking the NK1.1 antigen.

Abbreviation

CD49b

Gene ID

16398

UniProt

Q62469

Host

Rat

Reactivity

Mouse

Target

CD49 antigen-like family member B; CD49b; Collagen receptor; GPIa; Integrin alpha-2; Platelet membrane glycoprotein Ia; VLA-2 subunit alpha; pan-NK cells

Clonality

Monoclonal

Clone

DX5

Conjugation

Biotin

Applications

FCM

Field of Research

Cell Adhesion; Cell Biology; Immunology; Innate Immunity

Concentration

0.5 mg/mL

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Do not freeze.

Recommended Usage

6

Isotype

Rat IgM, κ