AF/LE Purified Anti-Mouse TCR γ/δ Antibody[UC7-13D5]

Specifications

Catalog number

E-AB-F11240-01

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ) . TCR γ/δ belongs to the immunoglobulin superfamily, involved in the recognition of certain bacterial and tumor antigens bound to MHC class I. The TCR γ/δ associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are CD4-/CD8-, some are CD8+. T cells expressing the TCR γ/δ have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease. It has been reported that γ/δ T cells also play a principal role in antigen presentation. Immobilized UC7-13D5 antibody has been reported to activate TCR-γ/δ-bearing T cells in vitro, and to deplete peripheral TCR-γ/δ-bearing T cells in vivo.

Abbreviation

TCR γ/δ

Host

Armenian Hamster

Reactivity

Mouse

Target

Γ/δ TCR; TCR-γ/δ

Clonality

Monoclonal

Clone

UC7-13D5

Conjugation

None (AF/LE)

Applications

FCM

Field of Research

Adaptive Immunity; Immunology

Concentration

≥ 1 mg/mL

Buffer

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Recommended Usage

6

Isotype

Armenian Hamster IgG