AF/LE Purified Anti-Human CD279/PD-1 Antibody[J116]

Specifications

Catalog number

E-AB-F11290-01

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2) . It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

Abbreviation

CD279

Gene ID

5133

UniProt

Q15116

Host

Mouse

Reactivity

Human

Immunogen

Recombinant Human CD279 protein

Target

Programmed Death-1; PD-1

Clonality

Monoclonal

Clone

J116

Conjugation

None (AF/LE)

Applications

FCM

Field of Research

Cancer Biomarkers; Immunology; Inhibitory Molecules

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Recommended Usage

6

Isotype

Mouse IgG1, κ