PerCP/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody[29F.1A12]

Specifications

Catalog number

E-AB-F1131J-01

Size / count

50 Tests

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2) . It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

Abbreviation

CD279

Gene ID

18566

UniProt

Q02242

Host

Rat

Reactivity

Mouse

Target

Programmed Death-1; PD-1

Clonality

Monoclonal

Clone

29F.1A12

Conjugation

PerCP/Cyanine 5.5

Applications

FCM

Field of Research

Cancer Biomarkers; Immunology; Inhibitory Molecules

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation 01

https://jitc.bmj.com/content/12/2/e008226.abstract

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Rat IgG2a, κ