FITC Anti-Mouse CD274/PD-L1 Antibody[10F.9G2]

Specifications

Catalog number

E-AB-F1132UC-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

Abbreviation

CD274

Gene ID

60533

UniProt

Q9EP73

Host

Rat

Reactivity

Mouse

Target

B7H1PD-L1PDCD1L1PDCD1LG1PDL1; B7 homolog 1; B7-H; B7-H1; Programmed cell death ligand 1

Clonality

Monoclonal

Clone

10F.9G2

Conjugation

FITC

Applications

FCM

Field of Research

Cancer Biomarkers; Costimulatory Molecules; Immunology

Concentration

0.5 mg/mL

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Recommended Usage

6

Isotype

Rat IgG2b, κ