APC Anti-Human CD274/PD-L1 Antibody[29E.2A3]

Specifications

Catalog number

E-AB-F1133E-01

Size / count

20 Tests

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1) . This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

Abbreviation

PD-L1

Gene ID

29126

UniProt

Q9NZQ7

Host

Mouse

Reactivity

Human

Target

B7H1PD-L1PDCD1L1PDCD1LG1PDL1; B7 homolog 1; B7-H; B7-H1; Programmed cell death ligand 1

Clonality

Monoclonal

Clone

29E.2A3

Conjugation

APC

Applications

FCM

Field of Research

Cancer Biomarkers; Costimulatory Molecules; Immunology

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation 01

https://link.springer.com/article/10.1007/s11427-024-2706-2

Citation 02

https://www.sciencedirect.com/science/article/pii/S0929664624002560

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Mouse IgG2b, κ