Elab Fluor® 488 Anti-Human CD107a/LAMP-1 Antibody[H4A3]

Specifications

Catalog number

E-AB-F1149L-01

Size / count

20 Tests

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40 kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation, CD107a is transferred to the cell membrane surface of activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107a has been suggested to play a role in the protection of lysosomal membrane from lysosomal hydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surface expression of LAMP-1 has been shown to correlate with CD8+ T cell and NK cell cytotoxicity.

Abbreviation

CD107a

Gene ID

3916

UniProt

P11279

Host

Mouse

Reactivity

Human

Target

LAMP-1LGP-120; Lysosome-Associated Membrane Protein 1; LAMP-1

Clonality

Monoclonal

Clone

H4A3

Conjugation

Elab Fluor®488

Applications

FCM

Field of Research

Cell Biology; Immunology; Neurodegeneration; Neuroscience; Protein Trafficking and Clearance

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Mouse IgG1, κ