Elab Fluor® 488 Anti-Human CD127/IL-7RA Antibody[A019D5]

Specifications

Catalog number

E-AB-F1152L-01

Size / count

20 Tests

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage cells, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker for identifying memory and effector T cells. Studies have shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.

Abbreviation

CD127

Gene ID

3575

UniProt

P16871

Host

Mouse

Reactivity

Human

Target

CD127; CDw127; IL-7RA; IL-7Rα; Interleukin-7 receptor subunit alpha

Clonality

Monoclonal

Clone

A019D5

Conjugation

Elab Fluor®488

Applications

FCM

Field of Research

Immunology

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation 01

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509016/

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Mouse IgG1, κ