APC Anti-Human CD196/CCR6 Antibody[G034E3] — image 1 of 2

Product details

APC Anti-Human CD196/CCR6 Antibody[G034E3]

Catalog number E-AB-F1158E-01

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Price for E-AB-F1158E-01

Size / count 20 Tests

Specifications

Catalog number: E-AB-F1158E-01
Size / count: 20 Tests
Dry ice: No
Hazardous: No
Discontinued: No
Background: CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs) . CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.
Abbreviation: CD196
Gene ID: 1235
UniProt: P51684
Host: Mouse
Reactivity: Human
Target: CMKBR6; GPR29; STRL22; CKRL3; GPRCY4; CCR6
Clonality: Monoclonal
Clone: G034E3
Conjugation: APC
Applications: FCM
Field of Research: Immunology
Concentration: 5 μL/Test
Buffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Shipping Conditions: Ice bag
Storage Conditions: This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Citation 01: https://cmjournal.biomedcentral.com/articles/10.1186/s13020-024-00904-2
Recommended Usage: The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .
Isotype: Mouse IgG2b, κ

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