AF/LE Purified Anti-Mouse CD366/Tim-3 Antibody[RMT3-23]

Specifications

Catalog number

E-AB-F11920-01

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells) . Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

Abbreviation

CD366/Tim-3

Gene ID

171285

UniProt

Q8VIM0

Host

Rat

Reactivity

Mouse

Target

TIMD3; HAVcr-2; TIM3; TIMD-3

Clonality

Monoclonal

Clone

RMT3-23

Conjugation

None (AF/LE)

Applications

FCM; Block

Field of Research

Immunology; Inhibitory Molecules

Concentration

≥ 1 mg/mL

Buffer

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Recommended Usage

6

Isotype

Rat IgG2a, κ