AF/LE Purified Anti-Human CD28 Antibody[CD28.2]

Specifications

Catalog number

E-AB-F11950-01

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.

Abbreviation

CD28

Gene ID

940

UniProt

P10747

Host

Mouse

Reactivity

Human

Target

GPSAT; GYPA; HGpMiX; MNS; PAS2

Clonality

Monoclonal

Clone

CD28.2

Conjugation

None (AF/LE)

Applications

FCM; Activ

Field of Research

Costimulatory Molecules; Immunology

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Citation 01

https://www.liebertpub.com/doi/abs/10.1089/jir.2023.0043

Recommended Usage

6

Isotype

Mouse IgG1, κ