AF/LE Purified Anti-Human CD20 Antibody[2H7]

Specifications

Catalog number

E-AB-F12120-01

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn) . It exists in a complex with MHC class I and II, CD53, CD81, and CD82.

Abbreviation

CD20

Gene ID

931

UniProt

P11836

Host

Mouse

Reactivity

Human

Immunogen

Recombinant Human CD20 protein

Target

B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; MS4A1

Clonality

Monoclonal

Clone

2H7

Conjugation

None (AF/LE)

Applications

FCM

Field of Research

Costimulatory Molecules; Immunology

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Recommended Usage

6

Isotype

Mouse IgG2b, κ