AF/LE Purified Anti-Human CD279/PD-1 Antibody[J110]

Specifications

Catalog number

E-AB-F12130-01

Size / count

100 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

Abbreviation

CD279/PD-1

Gene ID

5133

UniProt

Q15116

Host

Mouse

Reactivity

Human

Target

PD1; PDCD1; Protein PD-1; hPD-1

Clonality

Monoclonal

Clone

J110

Conjugation

None (AF/LE)

Applications

FCM

Field of Research

Cancer Biomarkers; Immunology; Inhibitory Molecules

Concentration

≥ 1 mg/mL

Buffer

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Recommended Usage

6

Isotype

Mouse IgG1, κ