APC Anti-Human CD279/PD-1 Antibody[EH12.2H7]

Specifications

Catalog number

E-AB-F1229E-01

Size / count

20 Tests

Dry ice

No

Hazardous

No

Discontinued

No

Background

Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

Abbreviation

CD279

Gene ID

5133

UniProt

Q15116

Host

Mouse

Reactivity

Human

Target

PD1; PDCD1; Protein PD-1; hPD-1

Clonality

Monoclonal

Clone

EH12.2H7

Conjugation

APC

Applications

FCM

Field of Research

Cancer Biomarkers; Immunology; Inhibitory Molecules

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation 01

https://link.springer.com/article/10.1007/s11427-024-2706-2

Citation 02

https://www.sciencedirect.com/science/article/pii/S1043466622002174

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Mouse IgG1, κ