APC Anti-Mouse CD105 Antibody[MJ7/18]

Specifications

Catalog number

E-AB-F1233UE-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and upregulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF-β1, TGF-β3 and modulates TGF-β signaling by interacting with TGF-β receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2, and BMP-7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging and prognosis, and has therapeutic potential for some solid tumors and other angiogenic diseases.

Abbreviation

CD105

Gene ID

13805

UniProt

Q63961

Host

Rat

Reactivity

Mouse

Target

END; Endoglin; Eng

Clonality

Monoclonal

Clone

MJ7/18

Conjugation

APC

Applications

FCM

Field of Research

Angiogenesis; Cell Adhesion; Cell Biology; Immunology; Stem Cells

Concentration

0.2 mg/mL

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Recommended Usage

6

Isotype

Rat IgG2a, κ