APC Anti-Mouse CD51 Antibody[RMV-7]

Specifications

Catalog number

E-AB-F1235E-01

Size / count

50 Tests

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD51 is a 140 kD protein, also known as αV integrin, vitronectin receptor, and integrin αV. It is a member of the integrin family, expressed on activated T cells, polymorphonuclear granulocytes, platelets, blastocysts, and osteoclasts. CD51 forms heterodimers by association with integrins β1, β3, β5 or β6; these complexes then act as receptors for multiple extracellular matrix proteins (ECM) . The αvintegrin heterodimers have varied functions in development, stimulation/activation and homeostasis. The primary ligands for CD51 complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.

Abbreviation

CD51

Gene ID

16410

UniProt

P43406

Host

Rat

Reactivity

Mouse

Target

ITGAV; Integrin alpha-V; Integrin αV chain; Vitronectin Receptor; αV integrin

Clonality

Monoclonal

Clone

RMV-7

Conjugation

APC

Applications

FCM

Field of Research

Angiogenesis; Cell Adhesion; Cell Biology; Costimulatory Molecules; Immunology; Innate Immunity; Stem Cells

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation 01

https://www.nature.com/articles/s41467-023-44312-w

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Rat IgG1, κ