FITC Anti-Human CD16 Antibody[3G8]

Specifications

Catalog number

E-AB-F1236C-01

Size / count

20 Tests

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD16 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD16 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD16 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD16 appears to be expressed later in the immune response than CD86. CD16 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

Abbreviation

CD16

Gene ID

941

UniProt

P08637; O75015

Host

Mouse

Reactivity

Human; Rhesus; Cynomolgus

Target

Fc gamma receptor; Fc gamma receptor 3; FcγRIII

Clonality

Monoclonal

Clone

3G8

Conjugation

FITC

Applications

FCM

Field of Research

Immunology; Innate Immunity

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation 01

https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1446710/full

Citation 02

https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1433076/full

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Mouse IgG1, κ