APC Anti-Mouse CD107a/LAMP-1 Antibody[1D4B]

Specifications

Catalog number

E-AB-F1254E-01

Size / count

50 Tests

Dry ice

No

Hazardous

No

Discontinued

No

Background

The 1D4B antibody recognizes CD107a which is also known as, Lysosome-Associated Membrane Protein 1 (LAMP-1) . CD107a is one of the two major glycoproteins in lysosome membranes that provide useful markers to distinguish lysosomes from other organelles. CD107a may play a role in the lysosomal degradation of certain molecules. Mouse CD107a is a type I transmembrane glycoprotein. It consists of a 40-kDa core protein which is heavily glycosylated to form heterogeneous mature glycoprotein of 110-140 kDa. It is principally expressed in epithelial cells and macrophages in a variety of organs. Following activation, CD107a is relocated to the surface of some lymphocytes, macrophages, epithelial cells, endothelial cells, platelets, and tumor cells. Cell-surface CD107a may participate in intercellular adhesion and adhesion to the extracellular matrix. Cell surface CD107a expression can serve as a useful marker for cytotoxic NK and CD8+ T cells, as well as, some malignant tumor cells.

Abbreviation

CD107a

Gene ID

16783

UniProt

P11438

Host

Rat

Reactivity

Mouse

Target

CD107 antigen-like family member Alysosomal membrane glycoprotein 1lysosome-associated membrane protein 1; LAMP-1; Lysosome-associated membrane glycoprotein 1; LAMP-1

Clonality

Monoclonal

Clone

1D4B

Conjugation

APC

Applications

FCM

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation 01

https://www.sciencedirect.com/science/article/pii/S0168365923006284

Citation 02

https://pubs.acs.org/doi/abs/10.1021/acsami.5c03195

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Rat IgG2a, κ