Purified Anti-Human CD8a Antibody[HIT8a]

Specifications

Catalog number

E-AB-F1271A-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers) . CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.

Abbreviation

CD8a

Gene ID

925

UniProt

P01732

Host

Mouse

Reactivity

Human

Target

CD8; Leu-2; Ly-2; CD8; CD8 antigen alpha po; CD8 antigen alpha polypeptide; CD8A; Leu; Leu2; MAL; T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu; T-lymphocyte differentiation antigen T8/Leu-2; T8; alpha polypeptide (p32) ; p32

Clonality

Monoclonal

Clone

HIT8a

Conjugation

Unconjugated

Applications

FCM

Field of Research

Immunology

Concentration

≥ 1 mg/mL

Buffer

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Recommended Usage

6

Isotype

Mouse IgG1, κ