Purified Anti-Mouse IL-17A Antibody[17F3]

Specifications

Catalog number

E-AB-F1272A-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The 17F3 monoclonal antibody reacts with mouse IL-17A a 15-20 kDa cytokine expressed by Th17 cells, γδ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. IL-17A has pleiotropic effects in immunoregulation and inflammation. It plays an important role in anti-microbial and chronic inflammation by inducing cytokine and chemokine production, neutrophil influx, and the production of antibacterial peptides but it is also an inflammatory mediator in the development of autoimmune diseases including rheumatoid arthritis, asthma, multiple sclerosis, and psoriasis. The 17F3 antibody has been shown to neutralize IL-18A in vivo.

Abbreviation

IL-17A

Gene ID

16171

UniProt

Q62386

Host

Mouse

Reactivity

Mouse

Target

Ctla9; Il17a; Interleukin-17A

Clonality

Monoclonal

Clone

17F3

Conjugation

Unconjugated

Applications

ICFCM

Field of Research

Cell Biology; Immunology; Neuroinflammation; Neuroscience

Concentration

≥ 1 mg/mL

Buffer

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Recommended Usage

6

Isotype

Mouse IgG1, κ