APC Anti-Human CD22 Antibody[HIB22]

Specifications

Catalog number

E-AB-F1321E-01

Size / count

20 Tests

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD22 is a 130 kD type I transmembrane glycoprotein also known as Siglec-2 and BL-CAM. It is a member of the immunoglobulin superfamily (sialoadhesion subgroup) . CD22 is expressed in the cytoplasm of pro-B and pre-B cells, and on the surface of mature B and activated B cells, but not on plasma cells. CD22 is present in the B cell receptor complex and associates with SHP-1, Syk, Lck, Lyn, and phospholipase Cγ1. A primary function of CD22 is thought to be in limiting antigen receptor signaling by modulating B cell activation threshold. CD22 has been shown to bind to CD45RO and CD75, although the natural ligands for this molecule remain controversial.

Abbreviation

CD22

Gene ID

933

UniProt

P20273

Host

Mouse

Reactivity

Human

Target

Siglec2; B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; CD22; Cd22; Lyb-8; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14

Clonality

Monoclonal

Clone

HIB22

Conjugation

APC

Applications

FCM

Field of Research

Immunology

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Mouse IgG1, κ