COL1A2 Polyclonal Antibody

Specifications

Catalog number

E-AB-10155-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Abbreviation

COL1A2

UniProt

P08123

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant protein of human COL1A2

Target

Alpha 2 collagen type I; Alpha 2 type I collagen; Alpha 2 type I procollagen; Alpha 2 (I) collagen; Alpha 2 (I) procollagen; Alpha-2 type I collagen; CO1A2; COL1A2; Collagen alpha 2 (I) chain; Collagen alpha-2 (I) chain; Collagen I alpha 2 polypeptide; Collagen of skin tendon and bone alpha 2 chain; Collagen type I alpha 2; OI4; Osteogenesis imperfecta type IV; Type I procollagen

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC

Field of Research

Cancer; Signal Transduction; Stem Cells

Purification

Affinity purification

Concentration

0.1 mg/mL

Dilution

IHC 1:100-1:300

Buffer

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG