BABAM2 Polyclonal Antibody

Specifications

Catalog number

E-AB-11008-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Brain and reproductive organ-expressed protein (BRE) is a 415 amino acid protein which binds to the intracellular juxtamembrane domain of the death receptor, tumor necrosis factor receptor 1 (TNF-R1) . BRE also binds to the death receptor, FAS. BRE downregulates TNFa-induced activation of NFkB and may play a role in homeostasis or cellular differentiation in cells of epithelial, neural and germ line origins. It inhibits components of the death-inducing signaling complexes that are necessary for activation of the mitochondria, thereby mediating apoptosis. BRE is strongly expressed in the adrenal cortex, medulla, testis and pancreas, and is weakly expressed in the thymus, thyroid, stomach and small intestine.

Abbreviation

BRE

UniProt

Q9NXR7

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant protein of human BRE

Target

6030405P19Rik; AI429776; B830038C02Rik; Brain and reproductive organ expressed (TNFRSF1A modulator) ; brain and reproductive organ expressed protein; Brain and reproductive organ-expressed protein; BRCA1 A complex subunit BRE; BRCA1-A complex subunit BRE; BRCA1/BRCA2 containing complex subunit 4; BRCA1/BRCA2 containing complex subunit 45; BRCA1/BRCA2-containing complex subunit 45; BRCC4; BRCC45; bre; BRE

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cancer; Cell Biology; Epigenetics and Nuclear Signaling

Purification

Affinity purification

Concentration

0.5 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:50-1:200

Buffer

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

44kDa

Isotype

IgG