DCTN4 Polyclonal Antibody

Specifications

Catalog number

E-AB-11145-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Dynactin is a multisubunit complex and a required cofactor for most, or all, of the cellular processes powered by the microtubule-based motor cytoplasmic dynein . Dynactin contains a short actin-related protein 1 (Arp1) filament with capZ at the barbed end and p62 at the pointed end . The p62 subunit is an integral component of 20 S dynactin with a highly conserved cysteine-rich motif that interacts directly with Arp1. Dynactin p62 has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin . In addition, Dynactin p62 is distributed in the nucleus at very high expression levels . Due to the structural composition of dynactin, the p62 subunit is implicated in Arp1 pointed-end binding and in linking dynein and dynactin to the cortical cytoskeleton.

Abbreviation

DCTN4

UniProt

Q9UJW0

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant protein of human DCTN4

Target

DCTN 4; Dctn4; DCTN4; Dynactin 4 (p62) ; Dynactin 4; Dynactin p62 subunit; Dynactin subunit 4; Dynactin subunit p62; Dynactin4; p62

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC

Field of Research

Cancer; Signal Transduction

Purification

Affinity purification

Concentration

0.9 mg/mL

Dilution

IHC 1:100-1:300

Buffer

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG